Extreme athlete turned government operative Xander Cage (Vin Diesel) comes out of self-imposed exile, thought to be long dead, and is set on a collision course with deadly alpha warrior Xiang (Donnie Yen) and his team in a race to recover a sinister and seemingly unstoppable weapon known as Pandora's Box. Recruiting an all-new group of thrill-seeking cohorts, Xander finds himself enmeshed in a deadly conspiracy that points to collusion at the highest levels of world governments.

The mercenary Royce; the military Isabelle; the Russian soldier Nikolai; the San Quentin criminal Stans; the Sierra Leone militia Mombasa; the drug lord Cuchillo; the Yakuza Hanzo; and the Doctor Edwin awake in free fall but they succeed to open their parachutes landing in a jungle. Soon they discover that they are on another planet and they are prey of aliens in a deadly hunting game, and they need to join forces to destroy their predators and survive.